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Glucotrol XL Dosage and Administration
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Glucotrol, Glucotrol XL, more Administer the nearest equivalent immediate-release daily dose as extended-release tablet once daily, glucotrol and fetal defects. Observe patients carefully for weeks when being converted from long half-life sulfonylureas to glipizide, because of potential for overlapping of hypoglycemic effects. Discontinue insulin and initiate glipizide therapy at recommended dose.
Because elderly patients are susceptible to the hypoglycemic effects of glucose-lowering drugs, the question of how tightly glucose levels should be controlled in the elderly is controversial.
Monitoring other parameters associated with lamictal and lorazapam disease, glucotrol and fetal defects, such as blood pressure and cholesterol, may be more important than normalized glycemic control. If patient is exposed to stress fever, trauma, infection, surgeryit may be necessary to discontinue glipizide and initiate insulin.
FDA-approved product labeling for many medications have included a broad contraindication in patients with a prior allregic reaction to sulfonamides; however, recent studies have suggested that crossreactivity between antibiotic sulfonamides and nonantibiotic sulfonamides is unlikely to occur; increase in cardiovascular mortality suggested by product labeling but data is limited. Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, when alcohol is ingested, or when more than one glucose-lowering drug is used.
Hemolytic anemia may occur with glucose 6-phosphate dehydrogenase G6PD deficiency when treated with sulfonylurea agents; consider a nonsulfonylurea alternative. Avoid using the extended-release tablets in patients with severe gastrointestinal narrowing of esophageal dysmotility.
Loss of efficacy glucotrol and fetal defects prolonged use possible; if no contributing factors, to explain loss of efficacy identified, consider discontinuing therapy; additional antidiabetic therapy will be required.
Available data from a small number of published studies and postmarketing experience with in pregnancy over decades have not identified any drug associated risks for major birth defects, miscarriage, or adverse maternal outcomes. However, sulfonylureas including glipizide cross the placenta and have been associated with neonatal adverse reactions such as hypoglycemia; therefore, therapy should be discontinued at least two weeks before expected delivery; poorly-controlled diabetes in pregnancy increases maternal risk for diabetic ketoacidosis, glucotrol and fetal defects, pre-eclampsia, miscarriage, glucotrol and fetal defects, preterm delivery, stillbirth, and delivery complications; poorly controlled diabetes increases fetal risk for major birth defects, stillbirth, and macrosomia related morbidity, glucotrol and fetal defects.
Neonates of women with gestational diabetes who are treated with sulfonylureas during pregnancy may be at increased risk for glucotrol and fetal defects intensive care admission and may develop respiratory distress, hypoglycemia, birth injury, and be large for gestational age; prolonged severe hypoglycemia, lasting days, has been reported in neonates born to mothers receiving glucotrol and fetal defects sulfonylurea at the time of delivery and has been reported glucotrol and fetal defects the use of agents with a prolonged half-life; observe newborns for symptoms of hypoglycemia and respiratory distress and manage accordingly.
Due to reports of prolonged severe hypoglycemia in neonates born to mothers receiving a sulfonylurea at time of delivery, therapy should be discontinued at least two weeks before expected delivery. Monitor breastfed infants for signs of hypoglycemia e. Controlled studies in pregnant women show no evidence of fetal risk.
Either animal studies show no risk but human studies not available or animal studies showed minor risks pregnancy and paxil human studies done and showed no risk.
Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. Positive evidence of human fetal risk. Do not use in pregnancy. Risks involved outweigh potential benefits. Initial effect to increase insulin secretion from pancreatic beta cells; may also decrease rate of hepatic glucose production and increase insulin receptor sensitivity.
Adding plans allows you to compare formulary status glucotrol and fetal defects other drugs in the same class. To view formulary information first create a list of plans. Your list will be saved and can be edited at any time. The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan itchy watery eyes and allergies for the most current information.
By clicking send, you acknowledge that you have permission to email the recipient with this information. If you log out, you will be required to enter your username and password the next time you visit, glucotrol and fetal defects. Brand and Other Names: Share Email Print Feedback Close. Extended-release tablets Glucotrol Glucotrol and fetal defects Initial: PO divided q12hr recommended.
Conversion From Immediate Release to Extended Release Administer the nearest equivalent immediate-release daily dose as extended-release tablet once daily Alternatively, administer 5 mg PO initially; titrate as necessary.
Conversion From Long Half-Life Agents Observe patients carefully for weeks when being converted from long half-life sulfonylureas to glipizide, because of potential for overlapping of hypoglycemic effects. Dosing Modifications Hepatic impairment: Dosing considerations Because elderly patients are susceptible to the hypoglycemic effects of glucose-lowering drugs, the question of how tightly glucose levels should be controlled in the elderly is controversial Recognizing hypoglycemia in elderly patients may be challenging Monitoring other parameters associated with cardiovascular disease, such as blood pressure and cholesterol, may be more important than normalized glycemic control Initial and maintenance dosing should be conservative.
Significant - Monitor Closely. All Interactions Sort By: Warnings Contraindications Hypersensitivity; sulfa allergy Type 1 diabetes Diabetic ketoacidosis with or without coma. Pharmacology Mechanism of Action Initial effect to increase insulin secretion from pancreatic beta cells; may also decrease rate of hepatic glucose production and increase insulin receptor sensitivity.
Initial effect 30 min ; max effect: Metabolism Extensively metabolized in liver to inactive metabolites Metabolites: Print without Office Info. Print with Office Info. Formulary Formulary Patient Discounts. Create Your List of Plans. View explanations for tiers and restrictions. Tier Description 1 This drug glucotrol and fetal defects available at the lowest co-pay.
Most commonly, glucotrol and fetal defects, these are generic drugs. Most commonly, these are "preferred" on formulary brand drugs. Most commonly, these are "non-preferred" brand drugs. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. Glucotrol and fetal defects restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. Non-Medicare Glucotrol and fetal defects Medicare Plans.
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
What would you like to print? Print this section Print the entire contents of. This website also contains material copyrighted by 3rd parties. Most Popular Articles According to Endocrinologists. Need a Curbside Consult? Share cases and questions with Physicians on Medscape consult, glucotrol and fetal defects. This drug is available at a middle level co-pay. This drug is available at a higher level co-pay.
Prior Authorization Drugs that require prior authorization. Quantity Limits Drugs that have quantity limits associated with each prescription. Step Therapy Drugs that have step therapy associated with each prescription. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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