Cancer of the pancreas is a genetic disease which means that it is caused by changes mutations in DNA. These changes can be inherited we are born with them or they can be acquired they develop after we are born.
The inherited changes explain why cancer of the pancreas runs in some families, and the acquired changes can be the result of either bad luck during cell replication or by exposure to carcinogens cancer causing chemicals such as those found in cigarette smoke.
The genetics of hereditary pancreatic cancer is a focus of research at Johns Hopkins. It has been estimated that ten percent of pancreatic cancers are hereditary, pancreatic cancer and awareness. Many of these occur as part of rare medical syndromes. We subscribe to the HONcode principles. This site is supported by generous educational grants from the Vesalius Trust. Home Donate Discussion Board. Expand All Collapse All. It was discovered in because of a remarkable advance made by the Hopkins team studying pancreatic cancer.
This mutation pancreatic cancer and awareness explain the higher rate of pancreatic cancer observed in Jews as compared to Catholics and Protestants.
Testing is now available for BRCA2 gene mutations. We advise that people speak with a trained cancer genetics counselor pancreatic cancer and awareness undergoing genetic testing. Peutz-Jeghers syndrome This is a very rare hereditary syndrome in which affected family members develop polyps in their small intestines and pigmented spots on their lips and inside of their mouth.
These polyps are masses of tissue that protrude from the normal surface of the intestine. Peutz-Jeghers is caused by inherited mutations in the STK11 pancreatic cancer and awareness. Patients with Peutz-Jeghers syndrome have an increased risk of developing pancreas cancer. Familial melanoma The Familial Atypical Multiple Mole Melanoma FAMMM syndrome is a rare hereditary syndrome in which affected family members develop skin moles and melanomas an aggressive form of skin cancer.
These patients also have an increased risk of developing pancreas cancer. Hereditary colon cancer The Hereditary Non-polyposis Colorectal Cancer HNPCC syndrome, also known as Lynch syndrome, strikes as many as 1 in individuals and it is characterized by the inherited predisposition to develop colon cancer, pancreatic cancer and awareness, endometrial uterine cancer, stomach cancer and ovarian cancer.
Hereditary pancreatitis This rare disease is characterized pancreatic cancer and awareness the development of recurrent episodes of severe chronic pancreatitis inflammation of the pancreas starting at an early age often in patients in their teens. The gene responsible for hereditary pancreatitis, called the trypsinogen gene, was discovered by Dr.
Whitcomb of the University of Pittsburgh, pancreatic cancer and awareness. Clinical gene testing for hereditary pancreatitis is now available. Ataxia telangiectasia The team at Johns Hopkins discovered that inherited mutations in the ATM gene also increase the risk of pancreatic cancer.
For example, pancreatic cancer and awareness, relatives of patients with pancreas cancer have an increased risk for developing pancreas cancer themselves, and the National Familial Pancreas Cancer Registry now contains over families in which two or more family members have had pancreas cancer. Scientists at Johns Hopkins are working diligently to discover the reasons why pancreas cancer runs in these families.
Anyone wishing to join this registry or wishing to learn more about familial pancreas cancer may contact Alison Klein at aklein1 jhmi.