Pancreatic cancer

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Pancreatitis and pancreatic cancer

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A risk factor is anything that affects your chance of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. But having a risk factor, or even many risk factors, does not mean that you will get the disease.

And many people who get the disease may have few or no known risk factors. Most of these are risk factors for exocrine pancreatic cancer. Pancreatitis and pancreatic cancer is one of the most important risk factors for pancreatic cancer.

The risk of getting pancreatic cancer is about twice as high among smokers compared to those who have never smoked. Cigar and pipe smoking also increase risk, as does the use of smokeless tobacco products.

Being overweight is a risk factor for pancreatic cancer. Carrying extra weight around the waistline may be a risk factor even in people who are not very overweight. The risk of developing pancreatic cancer goes up as people age.

Almost all patients are older than About two-thirds are at least 65 years old. The average age at the time of diagnosis is Men are slightly more likely to develop pancreatic cancer than women. This may be due, at least in part, to higher tobacco use in men, which raises pancreatic cancer risk see above.

The difference in pancreatic cancer risk was larger in the past when tobacco use was much more common among men than womenbut the gap has closed in recent years. African Americans are slightly more likely to develop pancreatic cancer than whites.

Pancreatic cancer seems to run in some families, pancreatitis and pancreatic cancer. In some of these families, pancreatitis and pancreatic cancer, the high risk is due to an inherited syndrome explained below.

In other families, the gene causing the increased risk is not known. Although family history is a risk factor, most people who get pancreatic cancer do not have a family history of it, pancreatitis and pancreatic cancer. Inherited gene changes mutations can be passed from parent to child. Sometimes these changes result in syndromes that include increased risks of other cancers or other health problems. Examples of genetic syndromes that can cause exocrine pancreatic cancer include:.

Pancreatitis and pancreatic cancer in the genes that cause some of these syndromes can be found by genetic testing. Pancreatic cancer is more common in people with diabetes. The reason for this is not known. Most of the risk is found in people with type 2 diabetes. This type of diabetes most often starts in adulthood and is often related to being overweight or obese.

Chronic pancreatitis, a long-term inflammation of the pancreas, is linked with an increased risk of pancreatic cancer especially in smokersbut most people with pancreatitis never develop pancreatic cancer. Chronic pancreatitis is sometimes due to an inherited gene mutation.

People with this inherited familial form of pancreatitis have a high lifetime risk of pancreatic cancer. Cirrhosis is a scarring of the liver. It develops in people with pancreatitis and pancreatic cancer damage from things like hepatitis and heavy alcohol use. People with cirrhosis seem to have an increased risk of pancreatic cancer. Infection of pancreatitis and pancreatic cancer stomach with the ulcer-causing bacteria Helicobacter pylori H, pancreatitis and pancreatic cancer.

Some research has suggested that excess stomach acid might also increase the risk. Some studies have linked pancreatic cancer to diets that are high in red and processed meats such as sausage and bacon and low in fruits and vegetables.

But not all studies have found such links, pancreatitis and pancreatic cancer, and this is still being studied. Some research has suggested that lack of physical activity might increase pancreatic cancer risk. But not all studies have found this. Some older studies have suggested that drinking coffee might increase the pancreatitis and pancreatic cancer of pancreatic cancer, but more recent studies have not confirmed this.

Some studies have shown a link between heavy alcohol use and pancreatic cancer. This link is still not certain, but heavy alcohol use can lead to conditions such as chronic pancreatitis and cirrhosis, which are known to increase pancreatic cancer risk.

March 14, pancreatitis and pancreatic cancer, Last Revised: For reprint requests, please see our Content Usage Policy. Can Pancreatic Cancer Be Prevented? Pancreatic Cancer Risk Factors. Risk factors that can be changed Tobacco use Smoking is one of the most important risk factors for pancreatic cancer. Overweight and obesity Being overweight is a risk factor for pancreatic pancreatitis and pancreatic cancer. Gender Men are slightly more likely to develop pancreatic cancer than women.

Race African Americans are slightly more likely to develop pancreatic cancer than whites. Family history Pancreatic cancer seems to run in some families. Inherited genetic syndromes Inherited gene changes mutations can be passed from parent to child.

Examples of genetic syndromes that can cause exocrine pancreatic cancer include: Peutz-Jeghers syndromecaused by defects in the STK11 gene. This syndrome is also linked with polyps in the digestive tract and several other cancers.

It can lead to an increased risk of pancreatic cancer and carcinoma of the ampulla of Vater. Pancreatic neuroendocrine tumors and cancers can also be caused by genetic syndromes, such as: Neurofibromatosis, type 1which is caused by mutations in the NF1 gene. This syndrome leads to an increased risk of many tumors, including somatostatinomas. This syndrome leads to an increased risk of tumors of the parathyroid gland, the pituitary gland, pancreatitis and pancreatic cancer, and the islet cells of the pancreas.

Diabetes Pancreatic cancer is more common in people with diabetes. Chronic pancreatitis Chronic pancreatitis, a long-term inflammation of the pancreas, is linked with an increased risk of pancreatic cancer especially in smokersbut most people with pancreatitis never develop pancreatic cancer.

Cirrhosis of the liver Cirrhosis is a scarring of the liver. Stomach problems Infection of the stomach with the ulcer-causing bacteria Helicobacter pylori H. Factors with unclear effect on risk Diet Some studies have linked pancreatic cancer to diets that are high in red and processed meats such as sausage and bacon and low in fruits and vegetables.

Physical inactivity Some research has suggested that lack of physical activity might increase pancreatic cancer risk. Coffee Some older studies have suggested that drinking coffee might increase the risk of pancreatic cancer, but more recent studies have not confirmed this. Alcohol Some studies have pancreatitis and pancreatic cancer a link between heavy alcohol use and pancreatic cancer.

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Pancreatitis and pancreatic cancer

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